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Blood protein clue to combating heart disease

March 16, 2012

PXR boosted anti-oxidant enzymes, which can reduce inflammation and lower the chance of a blockage, Dr Swales and colleagues at Queen Mary, University of London, found.

Results of their study, which looked at human tissue and blood vessel cells in the laboratory, are published in the journal Cardiovascular Research.

Dr Swales went on: “Heart and circulatory disease is the UK’s biggest killer. Discovering that the PXR protein could protect blood vessels has major implications for the prevention of cardiovascular disease.”

Dr David Bishop-Bailey, from Queen Mary’s William Harvey Research Institute, said: “We introduced specific PXR activating drugs and saw a co-ordinated increase in metabolising and anti-oxidant enzyme pathways.

“Since blood travels everywhere in the body, PXR has the potential to provide protection not just through its actions in the liver, but anywhere in the entire body.

“If we can work out how to manipulate PXR to turn on detoxification and antioxidant pathways in blood vessels, we may be a step closer to preventing our nation’s biggest killer.”

Article source: http://telegraph.feedsportal.com/c/32726/f/568308/s/1d592dac/l/0L0Stelegraph0O0Chealth0Chealthnews0C91371240CBlood0Eprotein0Eclue0Eto0Ecombating0Eheart0Edisease0Bhtml/story01.htm


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